The film opens in 2016 BCE with Sarman (Hrithik Roshan), a young man from the village of Amri, who lost his parents at a young age. Sarman kills a crocodile that has been terrorizing his village’s fishermen and is hailed as a hero. He asks his uncle, Durjan (Nitish Bharadwaj), to allow him to go to Mohenjo Daro to trade their family’s goods, but his uncle refuses. Sarman attempts to sneak away to the city at night with his friend Hojo (Umang Vyas), but is caught by Durjan, who relents and allows both friends to go. He gives Sarman a seal that contains an inscription of a unicorn that Sarman often sees in his dreams, suggesting he use it only once in a life or death situation.
Arriving in Mohenjo Daro, Sarman learns that the city is ruled by the tyrannical Senate Chief Maham (Kabir Bedi) and his wicked son Moonja (Arunoday Singh). He also learns that the unicorn he sees in his dreams is the symbol of the city, and feels as if the city is oddly familiar to him. While Sarman is trading, Maham proposes to impose an additional tax on the farmers so that the city may grow, but Sarman leads the farmers to oppose the taxes so that their families don’t starve to death. Sarman gains access to the upper city by showing his uncle’s amulet and meets Chaani (Pooja Hegde), the elegant and gorgeous daughter of the head priest (Manish Choudhary) Mohenjo Daro. Sarman is enchanted by Chaani’s heavenly beauty and charm and falls in love with her. Upon meeting, the head priest strangely appears to recognize Sarman. Chaani reveals that she has been forcibly betrothed to Moonja, Sarman’s enemy, who is cruel and ruthless. Maham discovers Sarman and Chaani love each other and that Sarman is the leader of the tax revolt, and so he challenges Sarman to fight Bakar and Zokhar, his two champions. Sarman proposes that if he wins, Chaani will be released from her engagement, and Maham accepts the terms.
The head priest reveals to Sarman how Maham was expelled from Harappa for illegal trade with the Sumerians. Maham entered Mohenjo Daro as a trader and quickly rose to become the trade chief. Maham had discovered that the mighty Sindhu River held vast gold deposits, so he decided to place a dam on the river and divert its course to mine the gold. The wise Senate Chief Srujan (Sharad Kelkar), who is revealed to be Sarman’s father, opposed this, but Maham won the vote to build the dam. He had Srujan framed and arrested for hoarding gold. Chaani’s father and Durjan – Sarman’s uncle – were coerced by Maham to betray Srujan, and the latter was killed. Maham then took Srujan’s place as the new Senate Chief. It is now up to Sarman to defeat the evil Maham and avenge for his father.
In the arena outside the city, Sarman faces the ferocious Tajik mountain cannibals Bakar and Zokhar. After a vicious battle, he kills one of the cannibals but spares the other, and the people of Mohenjo Daro surge even stronger behind him. Enraged, Maham urges Moonja to finish off Chaani and the priest. Moonja kills the priest, but Sarman saves Chaani and kills Moonja.
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